Thermo Fisher Scientific POM121 Polyclonal Antibody
Rabbit polyclonal antibody targeting human POM121, validated for WB and ICC/IF. Detects endogenous POM121 involved in nuclear pore complex formation. Supplied as unconjugated liquid form, 1 mg/mL concentration, stored at -20°C for research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human POM121 (Accession Q96HA1), corresponding to amino acid residues P1216–K1249 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852607 |
Product Specific Information
Antibody detects endogenous levels of total POM121.
Target Information
POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121), or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spliced isoforms and belongs to the POM121 family.
Encoded by a gene mapping to human chromosome 7q11.23, POM121 is highly conserved and localizes to the nuclear membrane and endoplasmic reticulum membrane.
As an essential component of the nuclear pore complex (NPC), POM121 is required for nuclear envelope formation and may play a role in NPC biogenesis. It associates with the central spoke ring complex and anchors components of the pore complex to the pore membrane via its F-X-F-G repeat-containing domain.
Overexpression of POM121 induces formation of cytoplasmic annulate lamellae (AL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-103243_POM121_A6NF01-1_Rabbit.svg, PA5-103243_POM121_Q96HA1-1_Rabbit.svg, PA5-103243_POM121_A8CG34-1_Rabbit.svg)
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