Thermo Fisher Scientific Caspr2 Recombinant Rabbit Monoclonal Antibody (001)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.

Advantages:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to large rabbit immune repertoire

This antibody has specificity for Mouse CNTNAP2/CASPR2.

Target Information

The CNTNAP2/CASPR2 gene encodes a member of the neurexin family, functioning in the vertebrate nervous system as cell adhesion molecules and receptors.
This protein contains epidermal growth factor repeats, laminin G domains, F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains, and a putative PDZ binding site.

It is localized at the juxtaparanodes of myelinated axons and mediates neuron–glia interactions during nervous system development. It also contributes to potassium channel localization in differentiating axons.

This gene accounts for ~1.5% of chromosome 7 and is among the largest genes in the human genome. It is directly regulated by FOXP2, associated with speech and language development.
Mutations or dysregulation have been implicated in neurodevelopmental disorders such as Tourette syndrome, schizophrenia, epilepsy, autism, ADHD, and mental retardation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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