Thermo Fisher Scientific CDCA7L Polyclonal Antibody
Thermo Fisher Scientific의 CDCA7L Polyclonal Antibody는 인간 CDCA7L 단백질을 인식하는 고품질 항체로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDCA7L. Recombinant protein control fragment (Product #RP-88699). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639577 |
Product Specific Information
Immunogen sequence:
VRFHSKYFTE ELRRIFIEDT DSETEDFAGF TQSDLNGKTN PEVMVVESDL SDDGKASLVS EEEEDEEEDK ATPRRSRSRR SSIGLRVAFQ FPTKKLANKP DKNSSSEQLF SSARLQNEKK TILERKKDCR QVIQREDSTS ESE
Highest antigen sequence identity to the following orthologs:
- Mouse: 60%
- Rat: 57%
Target Information
Cell division cycle-associated 7-like protein (CDCA7L, also known as RAM2) is a transcription factor involved in transcriptional regulation and apoptotic signaling pathways. It acts as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. CDCA7L plays an oncogenic role by mediating the transforming effects of MYC in medulloblastoma cells and may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3, CCND1/cyclin D1, and E2F1.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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