Thermo Fisher Scientific Phospho-Estrogen Receptor beta (Ser87) Polyclonal Antibody
인산화된 Estrogen Receptor beta(Ser87)를 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, IHC(P)에서 1:50–1:100 희석 비율로 사용 가능. Rabbit IgG 기반, 액상 형태이며 -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-Estrogen Receptor beta (Ser87) Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Estrogen Receptor-beta around the phosphorylation site of Ser87 (H-L-SP-P-L) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556325 |
Target Information
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55 kDa, though multiple isoforms ranging from 36–59 kDa have been described. Human ER beta was initially cloned and characterized from testis.
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins.
There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively).
Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues.
ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in various cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease, and cardiovascular disease risk.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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