Thermo Fisher Scientific FAIM3 Monoclonal Antibody (OTI1E6)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150
• View references

Product Specifications

Target Information

Apoptosis is an essential process for maintaining normal tissue homeostasis and function. Activation of the Fas receptor by its ligand triggers the formation of a Fas-associated death domain (FADD)-containing death-inducing signaling complex and the activation of caspase-8, which subsequently activates downstream effector caspases such as caspase-3 and -7.
Overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, has been shown to render Jurkat cells and transgenic mice resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Toso was found to associate with FADD, suggesting that it disrupts the formation of the death-inducing signaling complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.