Thermo Fisher Scientific CD74 Monoclonal Antibody (LN2), FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Biotin conjugate available (Cat. A15461)
• Custom conjugation upon request

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains five exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail. DRA lacks polymorphisms in the peptide-binding region and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The beta chain contains polymorphisms that determine peptide-binding specificity. HLA-DR is expressed mainly on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. DR, DQ, and DP loci encode the major human MHC class II molecules, which present processed peptides to T-helper cells, playing a crucial role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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