Thermo Fisher Scientific FRS3 Polyclonal Antibody
Human FRS3 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반의 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA556375
- 판매단위
- pk
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Thermo Fisher Scientific FRS3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FRS3. Recombinant protein control fragment (Product #RP-94864) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641751 |
Product Specific Information
Immunogen sequence:
EEPVIITRNS HPAELDLPRA PQPPNALGYT VSSFSNGCPG EGPRFSAPRR LSTSSLRHPS LGEESTHALI APDEQSHTYV NTPASEDDHR
Ortholog sequence identity:
- Mouse: 76%
- Rat: 78%
Target Information
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein containing one IRS-type PTB domain. It colocalizes to neural tissues with Tuj1 and functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, acting as a potential tumor suppressor.
FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and links c-Fgr and NGF receptors to downstream signaling pathways. It down-regulates ERK-2 expression by interfering with its phosphorylation and nuclear translocation. FRS3 interacts directly with GRB2, SH-PTP2, Flg, and Trk A and may be involved in MAP kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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