Thermo Fisher Scientific Phospho-GSK3 beta (Ser9) Polyclonal Antibody
인간 GSK3β의 인산화된 Ser9 잔기를 특이적으로 인식하는 폴리클로날 항체. Western blot, IHC, ELISA, IP 등 다양한 응용에 사용 가능. 친화 크로마토그래피로 정제된 액상 형태로, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 – 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 – 1:1,000 |
| ELISA | 1:10,000 – 1:50,000 |
| Immunoprecipitation (IP) | 1:500 – 1:3,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity purified antibody prepared from whole rabbit serum immunized with a synthetic peptide corresponding to a N-terminal region near aa 1–15 of human GSK3 beta. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02 M potassium phosphate, pH 7.2, with 0.15 M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid repeated freeze/thaw cycles.
- Centrifuge if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This affinity purified antibody is directed against the phosphorylated form of human GSK3B at the pS9 residue.
It specifically reacts with phosphorylated pS9 of human GSK3B, showing minimal reactivity with the non-phosphorylated form.
A BLAST analysis suggests reactivity with GSK3B from human, rat, frog, chicken, dog, and zebrafish based on 100% sequence homology.
Cross-reactivity with homologues from other species has not been determined.
Target Information
GSK3B (Glycogen Synthase Kinase 3 Beta) is a proline-directed serine/threonine protein kinase involved in:
- Energy metabolism and glucose homeostasis regulation
- Neuronal development and body pattern formation
- Inflammation, ER-stress, and apoptosis pathways
- Wnt/β-catenin signaling, where it mediates β-catenin degradation
- Hedgehog, Notch, and insulin signaling pathways
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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