Thermo Fisher Scientific ABH1 Polyclonal Antibody
ABH1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간과 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(40% glycerol) 용액 형태로 제공되며 -20°C에서 보관합니다.
- 카탈로그번호
- PA550290
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the N-terminal of human AlkB, alkylation repair homolog 1 (E. coli) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635743 |
Product Specific Information
This antibody detects endogenous levels of total ALKBH1 protein.
Target Information
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism for DNA alkylation damage repair. It functions in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine.
ALKBH1 is a dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. It requires molecular oxygen, alpha-ketoglutarate, and iron. The protein may play a role in placental trophoblast lineage differentiation and exhibits DNA lyase activity, introducing double-stranded breaks at abasic sites. It cleaves both single- and double-stranded DNA at abasic sites, with the highest activity toward double-stranded DNA containing two abasic sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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