Thermo Fisher Scientific TLX3 Monoclonal Antibody (5B11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

5B11

Immunogen

TLX3 (NP_066305, 192 a.a. approximately 291 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TLX3,uniProtId:O43711-1,ncbiNodeId:9606,antigenRange:192-291,antigenLength:291,antigenImageFileName:H00030012-M02_TLX3_O43711-1_House_mouse.svg,antigenImageFileNamePDP:H00030012-M02_TLX3_O43711-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: ASAERAALAK SLKMTDAQVK TWFQNRRTKW RRQTAEEREA ERQQASRLML QLQHDAFQKS LNDSIQPDPL CLHNSSLFAL QNLQPWEEDS SKVPAVTSLV

Target Information

The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.