Thermo Fisher Scientific Beclin 1 Polyclonal Antibody
Beclin 1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 오토파지 관련 연구에 유용합니다. 액상 형태로 -20°C 보관하며, PBS/glycerol buffer에 포함되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 25–280 of human Beclin 1 (NP_003757.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.34 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914093 |
Product Specific Information
Positive test controls include: 293T, Mouse lung, Mouse testis, Rat lung, Rat ovary.
The target is usually found in the following locations: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane.
Immunogen sequence:
LKLDTSFKIL DRVTIQELTA PLLTTAQAKP GETQEEETNS GEEPFIETPR QDGVSRRFIP PARMMSTESA NSFTLIGEAS DGGTMENLSR RLKVTGDLFD IMSGQTDVDH PLCEECTDTL LDQLDTQLNV TENECQNYKR CLEILEQMNE DDSEQLQMEL KELALEEERL IQELEDVEKN RKIVAENLEK VQAEAERLDQ EEAQYQREYS EFKRQQLELD DELKSVENQM RYAQTQLDKL KKTNVFNATF HIWHSG
Target Information
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play roles in multiple membrane trafficking pathways:
- PI3KC3-C1: involved in the initiation of autophagosomes
- PI3KC3-C2: involved in the maturation of autophagosomes and endocytosis
Beclin 1 also plays a role in antiviral host defense.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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