Thermo Fisher Scientific DDR2 Monoclonal Antibody (3E5)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:2,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3E5

Immunogen

This DDR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from human DDR2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DDR2,uniProtId:Q16832-1,ncbiNodeId:9606,antigenRange:290-320,antigenLength:855,antigenImageFileName:BSM-51147M_DDR2_Q16832-1_House_mouse.svg,antigenImageFileNamePDP:BSM-51147M_DDR2_Q16832-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Storage buffer

0.01M TBS, pH 7.4

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.