Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (TNKUSOHA), Alexa Fluor 700, eBioscience
인간 CD304(Neuropilin-1)을 인식하는 TNKUSOHA 단클론 항체로, Alexa Fluor 700 형광 표지. 유세포분석(Flow Cytometry)에 최적화되어 있으며, pDC 및 다양한 세포 유형의 발현 연구에 사용. 4°C 암조건 보관, 동결 금지.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 700, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TNKUSOHA |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574501 |
Available Formats
Product Specific Information
The TNKUSOHA monoclonal antibody recognizes human CD304 (also known as BDCA-4 and Neuropilin-1). CD304 is expressed on plasmacytoid dendritic cells in normal blood and bone marrow, as well as on T follicular helper cells in inflamed tonsils and some B-cell acute lymphoblastic leukemias. It is also found on non-hematopoietic cells including neurons, endothelial, and tumor cells.
Plasmacytoid dendritic cells play a key role in the innate immune response against viral pathogens and tumors.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and validated for flow cytometry using normal human peripheral blood cells
- Recommended Usage: 5 µL (0.125 µg) per test (defined as staining a cell sample in a final volume of 100 µL; 10⁵–10⁸ cells/test recommended)
Fluorochrome Characteristics:
- Alexa Fluor® 700 emits at 723 nm and is excited by the red laser (633 nm).
- Recommended filter setup: 685 LP mirror and 710/20 filter.
- Excitation: 633–647 nm; Emission: 723 nm; Laser: Red Laser.
- Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Neuropilin-1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin-1 forms heterodimers with NRP2 and binds plexin (PLXNB1) to form semaphorin receptors.
It is primarily expressed in the nervous system and is involved in:
- Cardiovascular system development
- Angiogenesis
- Axon guidance and neuronal circuit formation
- Cell survival and migration
- Organogenesis outside the nervous system
Neuropilin-1 also functions as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis. It may play a role in advanced prostate carcinoma and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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