Thermo Fisher Scientific TBC1D22A Polyclonal Antibody
TBC1D22A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간에 반응하며 마우스, 소에 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 단기 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 11–315 of Human TBC1D22A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2549492 |
Product Specific Information
- Recommended positive controls: A431, HeLa, HepG2
- Predicted reactivity: Mouse (85%), Bovine (82%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid protein containing one Rab-GAP TBC domain. It is thought to function as a GTPase-activating protein for Rab family members. Multiple isoforms exist due to alternative splicing.
The gene encoding TBC1D22A maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in genes on chromosome 22 are associated with Phelan-McDermid syndrome, neurofibromatosis type 2, autism, and schizophrenia.
Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the BCR-Abl fusion protein, a potent cell proliferation activator found in several types of leukemias.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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