Thermo Fisher Scientific KIR2DS2 Polyclonal Antibody
Thermo Fisher Scientific의 KIR2DS2 폴리클로날 항체는 사람 유래 단백질을 표적으로 하는 Rabbit IgG 형 항체로, WB와 ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 버퍼에 0.02% sodium azide를 포함합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KIR2DS2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KIR2DS2. The immunogen is located within the last 50 amino acids of KIR2DS2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890326 |
Product Specific Information
Positive controls that may be used include:
- HEK293 Cell Lysate
- HEK293 Cell Slide
Target Information
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain.
- Long cytoplasmic domain: transduces inhibitory signals via ITIM motif
- Short cytoplasmic domain: associates with TYRO protein tyrosine kinase binding protein to transduce activating signals
Ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins play an important role in regulation of immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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