Thermo Fisher Scientific OTUD7B Polyclonal Antibody
OTUD7B 단백질을 검출하기 위한 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. Human, Mouse, Rat 시료에 반응하며, 고순도 Affinity 정제 및 1 mg/mL 농도의 액상 형태로 제공. 연구용으로 NF-κB 경로 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human OTUD7B (Accession Q6GQQ9), corresponding to amino acid residues D757–C807. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854010 |
Product Specific Information
Antibody detects endogenous levels of total OTUD7B.
Target Information
OTUD7B is a negative regulator of the non-canonical NF-κB pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-κB pathway. It prevents TRAF3 proteolysis and over-activation of the pathway, thus modulating B-cell responses and mucosal immunity. OTUD7B also deubiquitinates ZAP70, regulating T cell receptor (TCR) signaling and T cell homeostasis. Additionally, it mediates deubiquitination of EGFR and shows activity toward Lys-11, Lys-48, and Lys-63 linked polyubiquitin chains. The physiological significance of its higher catalytic rate with Lys-11-linked chains remains uncertain.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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