Thermo Fisher Scientific MRCK alpha Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

3.75 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence SGEVRLRQLEQFI-C (aa 2-14). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MRCK alpha,uniProtId:Q5VT25-1,ncbiNodeId:9606,antigenRange:2-14,antigenLength:1732,antigenImageFileName:PA5-142110_MRCK_alpha_Q5VT25-1_Goat.svg,antigenImageFileNamePDP:PA5-142110_MRCK_alpha_Q5VT25-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2932771

Product Specific Information

Additional Information: This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

CDC42BPA (MRCKA) is a serine/threonine kinase which functions in actin cytoskeleton assembly and organization. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.