Thermo Fisher Scientific ATF7 Polyclonal Antibody
ATF7 단백질을 인식하는 Thermo Fisher Scientific의 고트 폴리클로날 항체로, WB 및 IHC(P) 적용 가능. 인간에 반응하며, 액상 형태로 0.5 mg/mL 농도. 세포 신호전달 및 전사 조절 연구에 적합.
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- PA517987
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Applications
- Western Blot (WB): 1–3 µg/mL
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HVIMTPQSQSAGR) corresponding to the C-terminus amino acids of ATF7 (aa 471–483) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986718 |
Product Specific Information
- Predicted to react with bovine, canine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
ATF7 plays important roles in early cell signaling and binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), found in many viral and cellular promoters. It activates the NF-ELAM1/delta-A site of the E-selectin promoter. Although it has no intrinsic transcriptional activity, ATF7 activates transcription when forming heterodimers with JUN or FOS. It can also bind TRE promoter sequences when heterodimerized with JUN family members.
Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities, possibly by sequestering the Thr-53 phosphorylating kinase in the cytoplasm, preventing activation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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