Thermo Fisher Scientific CD44v6 Monoclonal Antibody (CD44V6, 2496)
인간 CD44v6 단백질을 인식하는 Mouse IgG1 단클론 항체. IHC(파라핀 절편) 적용 가능하며, 고정 조직에서 Tris-EDTA 처리 후 사용. 세포 접착 및 이동 관련 CD44 연구에 적합. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD44V6, 2496 |
| Immunogen | Recombinant fragment corresponding to the v6 domain of human CD44 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
CD44 cell surface antigen is a 100 kDa glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast.
Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 acts as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration.
It also participates in lymphocyte activation, recirculation, and homing.
CD44 expression may be up-regulated in certain carcinomas, potentially related to metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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