Thermo Fisher Scientific XRCC4 Monoclonal Antibody (OTI4H9), TrueMAB
인간 XRCC4 단백질을 인식하는 마우스 단클론 항체로, WB와 IHC(P) 실험에 적합합니다. 1 mg/mL 농도의 동결건조 형태이며, PBS 버퍼에 8% 트레할로스 포함. DNA 복구 및 V(D)J 재조합 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H9 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human XRCC4 expression vector |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, it is recommended to add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficient DNA repair and maintaining genetic stability after base damage. These proteins share sequence similarity with the yeast DNA repair protein Rad51.
XRCC4 acts as an accessory factor of DNA ligase IV, binding preferentially to DNA with nicks or breaks. It enhances ligase IV activity and participates in V(D)J recombination.
Defects in components such as Ku-70, Ku-80, DNA-PKCS, XRCC4, or DNA ligase IV can lead to failure of V(D)J rearrangement and early blockage of T and B cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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