Thermo Fisher Scientific XRCC4 Monoclonal Antibody (OTI4H9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, it is recommended to add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficient DNA repair and maintaining genetic stability after base damage. These proteins share sequence similarity with the yeast DNA repair protein Rad51.
XRCC4 acts as an accessory factor of DNA ligase IV, binding preferentially to DNA with nicks or breaks. It enhances ligase IV activity and participates in V(D)J recombination.
Defects in components such as Ku-70, Ku-80, DNA-PKCS, XRCC4, or DNA ligase IV can lead to failure of V(D)J rearrangement and early blockage of T and B cell maturation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.