Thermo Fisher Scientific GMP synthase Polyclonal Antibody
Rabbit polyclonal antibody recognizing human GMP synthase region 650–693. Validated for WB and IP applications. Predicted reactivity with mouse, rat, and orangutan. Supplied as liquid, 0.2 mg/mL, stored at 4°C. For research use only.
- 카탈로그번호
- A302417Ax (2개 옵션)
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 and 693 of human guanine monophosphate synthetase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, and Orangutan
Target Information
Transcription factor that plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A).
The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) and histone modifying enzymes (such as SETD2), ensuring proper mRNA splicing, efficient mRNA export, and elongation-coupled H3K36 methylation — a hallmark of active transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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