Thermo Fisher Scientific A-Raf Polyclonal Antibody
Rabbit polyclonal antibody against human A-Raf protein for WB and IHC applications. High specificity and affinity purified via antigen chromatography. Supplied as liquid in PBS with glycerol and sodium azide, suitable for research use only.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARAF (Product #RP-103860) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791870 |
Product Specific Information
Immunogen sequence:
MSTNRQQFYH SVQDLSGGSR QHEAPSNRPL NELLTPQGPS PRTQHCDPEH FPFPAPANAP LQRIRSTST
Target Information
Several serine/threonine protein kinases act as intermediates in signal transduction pathways, including ERK/MAP kinases, ribosomal S6 kinase (Rsk), and Raf-1. Raf-1 is a cytoplasmic serine/threonine kinase broadly expressed in most cell lines and is homologous to v-Raf, the transforming gene product of murine sarcoma virus strain 3611. The unregulated kinase activity of v-Raf is linked to transformation and mitogenesis, while Raf-1 activity is normally suppressed by its N-terminal regulatory domain.
A-Raf, another member of the Raf family, shares substantial homology with Raf-1 within the kinase domain but less elsewhere. A-Raf expression is highest in urogenital tissues and kidney, and lowest in brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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