Thermo Fisher Scientific ITM2B Monoclonal Antibody (1A10)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
VHDFNKKLTA YLDLNLDKCY VIPLNTSIVM PPRNLLELLI NIKAGTYLPQ SYLIHEHMVI TDRIENIDHL GFFIYRLCHD KETYKLQRRE TIKGIQKREA

Target Information

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease.
This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide that inhibits beta-amyloid deposition.
Mutations that extend the C-terminal end of the encoded protein, increasing the size of the secreted peptide, are associated with familial British dementia and familial Danish dementia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.