Thermo Fisher Scientific HERPUD1 Monoclonal Antibody (OTI1A2), TrueMAB
HERPUD1 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 및 랫트 시료에 반응하며, TrueMAB 형식의 고품질 항체. ER 스트레스 및 단백질 분해 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A2 |
| Immunogen | Full length human recombinant protein of human HERPUD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes inhibition of translation to prevent further accumulation of unfolded proteins, increased expression of proteins involved in the unfolded protein response (UPR), and degradation of misfolded proteins via the ER-associated degradation (ERAD) system.
HERPUD1 may play a role in both UPR and ERAD. Its expression is induced by UPR, and it has an ER stress response element in its promoter region. The encoded protein contains an N-terminal ubiquitin-like domain that may interact with the ERAD system. HERPUD1 interacts with presenilin proteins and can increase amyloid-beta levels upon overexpression. Alternative splicing produces multiple transcript variants, though not all full-length isoforms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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