Thermo Fisher Scientific Lambda Light Chain Monoclonal Antibody (ICO106)
인간 Lambda light chain을 인식하는 Mouse monoclonal antibody (Clone ICO106). IHC와 Flow Cytometry에 적합하며, Protein A로 정제된 액상형 비결합 항체. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Lambda Light Chain Monoclonal Antibody (ICO106)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICO106 |
| Immunogen | Human IgG-lambda light chain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Tosil
- Cellular location: Cytoplasmic
Target Information
Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains and two light chains (kappa, lambda; both having a molecular weight of 22.5 kDa).
Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region.
The ratio of kappa to lambda is 70:30.
Antibodies to the kappa light chain are reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas.
Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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