Thermo Fisher Scientific ESR1 Monoclonal Antibody (OTI2D3), TrueMAB
인간 ESR1(Estrogen Receptor α)에 특이적인 단클론 항체로, WB 및 IHC(P)에서 검증됨. 마우스 IgG1 형식이며, 액상 상태로 제공. 고순도 친화 크로마토그래피 정제, 안정적 PBS/BSA/glycerol 버퍼 구성.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–310 of human ESR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. ER can regulate gene transcription positively or negatively through coactivator or corepressor recruitment.
Two forms of estrogen receptor exist — alpha (ESR1) and beta (ESR2) — encoded by separate genes. At least four isoforms of estrogen receptor-alpha are known (66 kDa, 53 kDa, 47 kDa, 35 kDa) due to alternative RNA splicing. Estrogen receptors are widely expressed and essential for sexual development, reproductive function, and bone maintenance. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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