Thermo Fisher Scientific Microphthalmia Transcription Factor (MITF) Monoclonal Antibody (MITF/915)
MITF 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간 및 개 시료에 반응합니다. IHC(P) 및 IHC(PFA)에서 사용 가능하며, Protein A/G로 정제된 1 mg/mL 액상 형태입니다. MiTF 관련 연구용으로 적합하며, 마우스 및 랫트에는 반응하지 않습니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MITF/915 |
| Immunogen | Recombinant full-length human MiTF protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse or Rat
Target Information
Mi (Microphthalmia transcription factor, MITF) is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor involved in pigmentation, mast cell, and bone development.
Mutations in Mi cause Waardenburg Syndrome type II in humans. In mice, loss of pigmented cells in skin, eye, and inner ear leads to osteopetrosis and defects in natural killer and mast cells.
Two isoforms exist, differing by 66 amino acids at the N-terminus. Shorter forms are expressed in melanocytes (52 kDa and 56 kDa), while longer forms (60–70 kDa) are found in osteoclasts, B16 melanoma cells, mast cells, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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