Thermo Fisher Scientific ARS2 Polyclonal Antibody
Rabbit polyclonal antibody against human ARS2 protein. Validated for WB, IHC, and IP applications. Provides high specificity and sensitivity for detecting ARS2. Suitable for research use only. Recommended storage at 4°C.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 826 to 876 of human Arsenate Resistance Protein 2 (ARS2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Zebrafish, X. laevis, Bovine, and Orangutan.
Target Information
ARS2 acts as a mediator between the cap-binding complex (CBC) and the primary microRNA (miRNA) processing machinery during cell proliferation. It contributes to the stability and delivery of capped primary miRNA transcripts to the processing complex containing DGCR8 and DROSHA, playing a role in RNA-mediated gene silencing by miRNAs.
ARS2 binds capped RNAs (m7GpppG-capped RNA), likely through interaction with the NCBP1/CBP80 component of the CBC complex. It is involved in cell cycle progression at the S phase and modulates arsenic sensitivity rather than directly conferring arsenite resistance. Independently of miRNA activity, ARS2 promotes neural stem cell self-renewal by binding to the SOX2 promoter and regulating its transcription.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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