Thermo Fisher Scientific Human CD180 Synthetic Peptide
인간 CD180 단백질의 중심부 14개 아미노산 서열 기반 합성 펩타이드로, 항체 차단 실험에 활용 가능. 액상 형태, PBS 버퍼에 0.1% BSA 포함. 연구용으로만 사용되며 CD180 관련 면역 반응 연구에 적합.
- 카탈로그번호
- PEP0374
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the center of human RP105.
PEP-0374 can be used as a blocking peptide with polyclonal antibody PA5-20252.
Target Information
CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of the Toll-like receptor (TLR) family.
Its cytoplasmic tail is short and lacks the TIR domain, unlike other TLRs.
CD180 expression depends on coexpression with its helper molecule MD-1 and mirrors TLR4 expression on antigen-presenting cells.
It regulates recognition of LPS and signaling in B cells by interacting directly with the TLR4 signaling complex, inhibiting microbial ligand binding.
Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.
CD180 consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail.
The extracellular LRR forms part of the RP105/MD-1 receptor complex.
Dysfunction of CD180 is associated with Kawasaki Disease and may play a role in rheumatic disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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