Thermo Fisher Scientific E2F6 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): Tested dilution 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY VSMRKALKVK RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIDLVEKKS KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL SAMEDALDEL IKDCAQQLFE LTDDKENERL AYVTYQDIHS IQAFHEQIVI AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ GQTSNKRSEG VGTSSSESTH PEGPEEEENP QQSEELLEVS N

Target Information

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and the action of tumor suppressor proteins. They are also targets of transforming proteins of small DNA tumor viruses.
Many E2F proteins contain several conserved domains: DNA binding domain, dimerization domain (interaction with DP proteins), transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain.
The encoded protein of E2F6 is atypical, lacking the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and acts as an inhibitor of E2F-dependent transcription.
E2F6 is part of a multimeric complex containing a histone methyltransferase and transcription factors Mga and Max. Multiple transcript variants have been reported, though their validity as isoforms remains unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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