Thermo Fisher Scientific MFN1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MFN1, validated for ICC/IF. Recombinant protein immunogen ensures high specificity. Supplied as liquid in PBS with glycerol for stability. Suitable for mitochondrial metabolism and apoptosis research.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MFN1. Recombinant protein control fragment (Product #RP-106921) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663957 |
Product Specific Information
Immunogen sequence:
SLGWSSLVHRF LGPRNAQRVL LGLSEPIFQL PRSLASTPTA PTTPATPDNA SQEELMITLV TGL
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 88%
Target Information
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion, essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 regulates Bax activation on the outer mitochondrial membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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