Thermo Fisher Scientific OLIG2 (Marker of Glial Brain Tumors) Recombinant Rabbit Monoclonal Antibody (OLIG2/7074R)
OLIG2 단백질을 인식하는 재조합 토끼 단일클론 항체로, 신경교종 등 뇌종양 연구에 적합. IHC(P) 및 PFA 고정 조직에 사용 가능. HEK293 세포 발현, Protein A/G 정제, 4°C 보관. 연구용 전용 시약.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | OLIG2/7074R |
| Immunogen | Recombinant fragment (around aa200–300) of human OLIG2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a basic helix-loop-helix transcription factor expressed in oligodendroglial tumors of the brain. The protein regulates ventral neuroectodermal progenitor cell fate and is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location on chromosome 21 may be linked to learning deficits in Down syndrome.
Tissue specificity: Expressed in the brain, particularly in oligodendrocytes. Strongly expressed in oligodendrogliomas, weak to moderate in astrocytomas, and variably in glioblastomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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