Thermo Fisher Scientific TLR7 Monoclonal Antibody (4G6)
TLR7 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot, ICC/IF, Flow cytometry 등 다양한 응용 가능. Human 및 Mouse 반응성. 고순도 Protein G 정제, 액상 형태로 제공. 연구용 전용 제품.
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Thermo Fisher Scientific TLR7 Monoclonal Antibody (4G6)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:500–1:5,000 | View 1 publication |
| Flow Cytometry (Flow) | 1–2 µg/1×10⁶ cells | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G6 |
| Immunogen | Synthetic peptide (277 amino acid, AA 562–839) of TLR7 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537765 |
Additional Formats
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family, containing 27 leucine-rich repeats (LRR) and a TIR domain. It plays a key role in pathogen recognition and activation of innate immunity.
TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV), and is predominantly expressed in lung, placenta, and spleen.
It interacts with MyD88 and TRAF6, leading to NF-κB activation, cytokine secretion, and inflammatory responses.
TLR7 recognizes pathogen-associated molecular patterns (PAMPs) and mediates cytokine production necessary for effective immune response.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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