Thermo Fisher Scientific p53AIP1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing p53AIP1, validated for WB and ELISA. Detects mouse and rat targets. Supplied as liquid, affinity purified, 0.39 mg/mL in PBS with 50% glycerol. Suitable for studying p53-regulated apoptosis pathways.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–108 of human TP53AIP1 (NP_001238893.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.39 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855921 |
Product Specific Information
Immunogen sequence:
MGSSSEASFR SAQASCSGAR RQGLGRGDQN LSVMPPNGRA QTHTPGWVSP CSENRDGLLP ATAPGRLCSH RGADIPSFQT HQDPVTASGS SELHADCPQF RALDRAGN
Target Information
The novel protein p53AIP1 (p53-regulated apoptosis-inducing protein 1) has been identified from direct cloning of p53 binding sequences from human genomic DNA. The expression of p53AIP1 in mitochondria is induced by wild-type p53, leading to apoptotic cell death through dissipation of mitochondrial potential. Severe DNA damage causes phosphorylation of p53 at Ser-46, p53AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptosis is enhanced through transcriptional activation of p53AIP1.
P53R2 is directly regulated by p53 to supply nucleotides for DNA repair, playing a key role in cell survival. Dysfunction of this pathway may activate p53-dependent apoptosis to eliminate damaged cells. Conversely, p53AIP1 plays an important role in mediating p53-dependent apoptosis, with phosphorylation at Ser46 regulating transcriptional activation of this apoptosis-inducing gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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