Thermo Fisher Scientific TRPM8 Polyclonal Antibody
TRPM8 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 초파리 반응성. 항원 친화 크로마토그래피로 정제되었으며, 냉감 수용체 연구에 적합. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:10–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:10–1:500 |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 |
| ELISA | 1:100–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Fruit fly, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to residues 278–292 (RNQLEKYISERTIQD) and the C-terminal sequence (NDLKGLLKEIANKIK) of the human TRPM8 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4 °C (short term). For long-term storage, store at −20 °C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1018584 |
Product Specific Information
Suggested positive control: antigen standard for TRPM8 (transient overexpression lysate).
Target Information
TRPM8 is a receptor-activated non-selective cation channel involved in detecting cool sensations, activated by cold temperatures below 25 °C as well as icilin, eucalyptol, and menthol. It is permeable to sodium, potassium, cesium, and calcium ions.
TRPM8 expression is primarily found in prostate epithelial cells, with moderate mRNA levels in normal prostate tissue and elevated expression in prostate cancer. It has also been detected in certain non-prostatic tumors (breast, colon, lung, skin) but rarely in corresponding normal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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