Thermo Fisher Scientific PTPN11 Monoclonal Antibody (OTI2F4), TrueMAB
PTPN11(SHP2) 단백질을 인식하는 Mouse 모노클론 항체로, Western blot과 유세포분석에 적합합니다. 고순도 Affinity chromatography 정제 제품이며, PBS/BSA/glycerol 완충액에 저장됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F4 |
| Immunogen | Full length human recombinant protein of human PTPN11 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the PTPN11 gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 (SH2) domains that mediate phospho-tyrosine binding and substrate interaction. It is widely expressed in most tissues and plays regulatory roles in signaling events related to mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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