Thermo Fisher Scientific HLA-DPB1 Monoclonal Antibody (6C6)
인간 HLA-DPB1 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ELISA에 사용 가능. 면역원은 GST 태그가 결합된 HLA-DPB1 전장 재조합 단백질. 면역펩타이드 분석 및 항원 제시 연구에 적합. 연구용으로만 사용.
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Thermo Fisher Scientific HLA-DPB1 Monoclonal Antibody (6C6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6C6 |
| Immunogen | HLA-DPB1 (AAH13184, 1–258 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYVYQG RQECYAFNGT QRFLERYIYN REEYARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA VPDRVCRHNY ELDEAVTLQR RVQPKVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYIC QVEHTSLDSP VTVEWKAQSD SAQSKTLTGA GGFVLGLIIC GVGIFMHRRS KKVQRGSA
Target Information
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26–28 kDa and its gene contains 6 exons:
- Exon 1: leader peptide
- Exons 2–3: extracellular domains
- Exon 4: transmembrane domain
- Exon 5: cytoplasmic tail
Within the DP molecule, both the alpha and beta chains contain polymorphisms specifying peptide binding specificities, resulting in up to 4 different molecules.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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