Thermo Fisher Scientific HLA-DPB1 Monoclonal Antibody (6C6)

Thermo Fisher Scientific HLA-DPB1 Monoclonal Antibody (6C6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYVYQG RQECYAFNGT QRFLERYIYN REEYARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA VPDRVCRHNY ELDEAVTLQR RVQPKVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYIC QVEHTSLDSP VTVEWKAQSD SAQSKTLTGA GGFVLGLIIC GVGIFMHRRS KKVQRGSA

Target Information

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26–28 kDa and its gene contains 6 exons:

• Exon 1: leader peptide
• Exons 2–3: extracellular domains
• Exon 4: transmembrane domain
• Exon 5: cytoplasmic tail

Within the DP molecule, both the alpha and beta chains contain polymorphisms specifying peptide binding specificities, resulting in up to 4 different molecules.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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