Thermo Fisher Scientific Ankyrin 1 Polyclonal Antibody
Ankyrin 1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. Human 시료에 반응하며 Protein A로 정제됨. 액상 형태로 1 mg/mL 농도. -20°C에서 보관, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human ANK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2609372 |
Product Specific Information
Peptide sequence:
VVRQIDLSSA DAAQEHEEVE LRGSGLQPDL IEGRKGAQIV KRASLKRGKQ
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Target Information
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner.
Most ankyrins are composed of three structural domains:
- Amino-terminal domain containing multiple ankyrin repeats
- Central region with a highly conserved spectrin binding domain
- Carboxy-terminal regulatory domain (least conserved and variable)
Ankyrin 1, the prototype of this family, was first discovered in erythrocytes and later found in brain and muscles. Mutations in erythrocytic ankyrin 1 are associated with hereditary spherocytosis. Complex alternative splicing in the regulatory domain gives rise to various isoforms of ankyrin 1, including truncated muscle-specific forms from alternate promoter usage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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