Thermo Fisher Scientific DTL Polyclonal Antibody
Rabbit polyclonal antibody targeting human DTL for IHC(P) applications. Recognizes recombinant DTL protein, purified via antigen affinity chromatography. Supplied in PBS with glycerol and sodium azide, stored at 4°C or -20°C. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DTL. Recombinant protein control fragment (Product #RP-94290). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640810 |
Product Specific Information
Immunogen sequence:
TVVLFQDENT LVSAGAVDGI IKVWDLRKNY TAYRQEPIAS KSFLYPGSST RKLGYSSLIL DSTGSTLFAN CTDDNIYMFN MTGLKTSPVA IF
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 95%
Target Information
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response, and translesion DNA synthesis.
The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1).
CDT1 degradation in response to DNA damage ensures proper cell cycle regulation of DNA replication.
CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation controls replication licensing.
Most substrates interact with PCNA via their PIP-box; those containing the K+4 motif recruit the DCX(DTL) complex, leading to degradation.
In undamaged proliferating cells, the DCX(DTL) complex promotes Lys-164 monoubiquitination of PCNA, involved in PCNA-dependent translesion DNA synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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