Thermo Fisher Scientific Desmin Recombinant Rabbit Monoclonal Antibody (23GB3120)
Desmin 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. HEK293F 발현 시스템에서 생산되며, 고순도 친화 크로마토그래피 정제. 근육세포 특이적 Desmin 검출에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3120 |
| Immunogen | A synthesized peptide derived from human Desmin (410–470AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle). Its expression is regulated in a stage- and tissue-specific manner, being induced during terminal development of skeletal muscle differentiation.
In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk. Expression in smooth muscle is more heterogeneous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, such as rhabdomyosarcomas and leiomyosarcomas.
During myocardial dysfunction, dramatic changes in desmin distribution have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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