Thermo Fisher Scientific CCL19 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is closely related to CCL21, sharing approximately 32% amino acid sequence homology. CCL19 and CCL21 are primarily expressed by stromal cells in the T cell-rich zones of lymph nodes and are critical mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs. They play key roles in T cell priming and activation, as well as lymphocyte recruitment to inflamed tissues. Both proteins signal via the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. Although both bind CCR7 with similar affinity, only CCL19 binding induces receptor desensitization and internalization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.