Thermo Fisher Scientific SRGAP2C Polyclonal Antibody
SRGAP2C 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, Protein G 정제 및 PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SLIT-ROBO Rho GTPase-activating protein 2C (1–242 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092294 |
Target Information
Human-specific protein that acts as a key modifier of cortical connectivity in the human brain. Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons.
SRGAP2C is unstable but can heterodimerize with SRGAP2/SRGAP2A, reducing its levels through proteasome-dependent degradation. Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to increased synaptic density and prolonged synaptic maturation of both excitatory and inhibitory synapses.
It modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons and enhances the probability of sensory-evoked responses by these neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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