ELK Biotechnology Histone H2A.Z (Acetyl Lys14) rabbit pAb
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| Product name: | Histone H2A.Z (Acetyl Lys14) rabbit pAb |
| Alternative Names: | Histone H2A.Z (H2A/z) |
| Applications: | WB; ELISA |
| Recommended Dilutions: | WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human Histone H2A.Z (Acetyl Lys14) |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 15kD |
| GeneID（Human）: | 3015 |
| Human Swiss-Prot No: | P0C0S5 |
| Cellular localization: | Nucleus. Chromosome. |
| Background: | function:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.,mass spectrometry:Monoisotopic, not modified PubMed:16457589,PTM:Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.,PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.,PTM:Not phosphorylated.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP., |
| Species Reactivity: | Human;Mouse;Rat |
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