ELK Biotechnology FoxO3A (Acetyl Lys569) rabbit pAb

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FoxO3A (Acetyl Lys569) rabbit pAb

기본 정보

세포 내 위치

Cytoplasm, cytosol, nucleus, mitochondrion matrix, mitochondrion outer membrane, peripheral membrane protein (cytoplasmic side).
Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106).
Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106).
Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity).
Translocates in an AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193).
Serum deprivation increases localization to the nucleus, leading to activation of SOX9 expression and subsequent chondrogenesis (By similarity).

Background

• Disease: A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.
• Function: Transcriptional activator triggering apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5-[AG]TAAA[TC]A-3.
• PTM: Phosphorylated on Thr-32 and Ser-253 by AKT1/PKB in the presence of survival factors such as IGF-1. This form interacts with 14-3-3 proteins and is retained in the cytoplasm. Dephosphorylation induces nuclear translocation and apoptosis. Phosphorylated by STK4 on Ser-209 upon oxidative stress, causing nuclear translocation.
• Similarity: Contains 1 fork-head DNA-binding domain.
• Subcellular location: Translocates to the nucleus upon oxidative stress and absence of survival factors.
• Subunit: Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta for cytosolic sequestration. Upon oxidative stress, interacts with STK4, disrupting YWHAB/14-3-3-beta interaction and promoting nuclear translocation.
• Tissue specificity: Ubiquitous.

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