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ELK Biotechnology FoxO1A (Acetyl Lys245) rabbit pAb
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FoxO1A 단백질의 Lys245 아세틸화를 인식하는 토끼 다클론 항체로, WB와 ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 세포 내 FoxO1A의 인산화 및 위치 이동 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology ES20066-100UL FoxO1A (Acetyl Lys245) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES20066-50UL FoxO1A (Acetyl Lys245) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology FoxO1A (Acetyl Lys245) rabbit pAb
FoxO1A (Acetyl Lys245) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FoxO1A (Acetyl Lys245) rabbit pAb |
| Alternative Names | Forkhead box protein O1 (Forkhead box protein O1A; Forkhead in rhabdomyosarcoma) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human FoxO1A (Acetyl Lys245) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 72 kD |
| GeneID (Human) | 2308 |
| Human Swiss-Prot No | Q12778 |
| Cellular Localization | Cytoplasm, Nucleus. Shuttles between cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus. Serum deprivation increases nuclear localization, activating SOX9 expression and chondrogenesis. Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads to nuclear export and degradation. Phosphorylation at Ser-249 by CDK1 promotes nuclear accumulation. |
| Background | Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2), also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3 or t(1;13)(p36;q14) with PAX7 results in transcriptional activator proteins. FOXO1 functions as a transcription factor. Phosphorylated by AKT1; insulin-induced. IGF1 induces phosphorylation at Ser-256, Thr-24, and Ser-319, decreasing DNA-binding activity and promoting nuclear exclusion. Phosphorylated upon DNA damage, likely by ATM or ATR. Contains one fork-head DNA-binding domain. Interacts with LRPPRC. Ubiquitously expressed. |
| Species Reactivity | Human, Mouse, Rat |
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