ELK Biotechnology Collagen IV α1 (Cleaved-Gly173) rabbit pAb

Collagen IV α1 (Cleaved-Gly173) Rabbit Polyclonal Antibody

제품 개요

Collagen IV α1 (Cleaved-Gly173) rabbit pAb는 인간 및 생쥐 시료에서 Collagen alpha-1(IV) chain을 인식하는 고품질의 polyclonal antibody입니다. 주로 glomerular basement membrane(GBM)과 관련된 구조 연구 및 질환 분석에 사용됩니다.

제품 정보

생물학적 배경

• Disease relevance:

  • Defects in COL4A1 are linked to brain small vessel disease with hemorrhage (MIM:607595), porencephaly type 1 (MIM:175780), and hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC, MIM:611773).
  • These disorders are typically autosomal dominant and involve structural basement membrane defects.

• Domain structure:

  • Type IV collagen α-chains possess a non-collagenous NC1 domain at the C-terminus, interruptions in the G-X-Y repeats, and a short N-terminal 7S domain.

• Function:

  • Type IV collagen forms the major structural component of glomerular basement membranes (GBM), creating a meshwork with laminins, proteoglycans, and entactin/nidogen.
  • It inhibits endothelial cell proliferation and angiogenesis, possibly via interactions with cell surface proteoglycans and integrins.

• Post-translational modifications (PTM):

  • Hydroxylation of lysine and proline residues within G-X-Y repeats.
  • Covalent stabilization of NC1 domain trimers via Lys-Met bonds.
  • Multiple conserved cysteine residues forming intra- and intermolecular disulfide bonds.

• Similarity:

  • Belongs to the type IV collagen family.
  • Contains one collagen IV NC1 (C-terminal non-collagenous) domain.

• Subunit structure:

  • Six isoforms (α1(IV)–α6(IV)) form triple helices to create the type IV collagen network.

• Tissue specificity:

  • Highly expressed in placenta.

제품 이미지

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