Thermo Fisher Scientific Aurora B Polyclonal Antibody
Aurora B 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ELISA, IP에 사용 가능. Human 시료 반응성. 합성 펩타이드(aa 300–344)로부터 유래. 액상 형태, 친화 크로마토그래피 정제, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region 300–344 on human Aurora Kinase B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Aurora kinases associate with microtubules during chromosome movement and segregation.
AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers.
This complex functions in chromosome alignment and separation, histone modification, and cytokinesis.
The chromosomal passenger complex (CPC) includes three non-enzymatic subunits — inner centromere protein (INCENP), survivin, and borealin — which determine the activity, localization, stability, and possibly substrate specificity of Aurora B.
Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora B.
The full CPC functions during chromosome alignment and cytokinesis, whereas the INCENP–AurB complex may be responsible for histone H3 modification.
AurB is overexpressed in several tumors, including primary breast and colon tumor samples. Its expression appears linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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