Thermo Fisher Scientific AXIN1 Monoclonal Antibody (E.882.7)
AXIN1 단백질 검출용 토끼 단클론 항체로 WNT 신호 조절 연구에 적합함. Western blot 및 Immunoprecipitation에 검증됨. 비결합형 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific AXIN1 Monoclonal Antibody (E.882.7)
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000
- Immunoprecipitation (IP): 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.882.7 |
| Immunogen | Recombinant protein consisting of the N-terminal region of human Axin1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10986569 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
AXIN1 is a cytoplasmic protein containing a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain. It functions as a negative regulator of the WNT signaling pathway, which controls embryonic axis formation. AXIN1 interacts with APC, beta-catenin, and glycogen synthase kinase 3 beta to form a tetrameric complex that regulates beta-catenin stabilization. Mutations in the AXIN1 gene are associated with various carcinomas, indicating its role as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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