Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI4F3), TrueMAB
인간 CCL19 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 실험에 적합합니다. 비결합형 액상 형태이며, 고순도의 친화 크로마토그래피 정제 제품입니다. PBS, BSA, 글리세롤 완충액에 보존되며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22-98 of human CCL19 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is closely related to CCL21, sharing 32% amino acid sequence homology. CCL19 and CCL21 are mainly expressed by stromal cells in T cell-rich zones of lymph nodes and are critical mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs. They also play roles in T cell priming, activation, and recruitment of lymphocytes to inflamed tissues. Both proteins signal via the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. While both have the same affinity for CCR7, only CCL19 binding results in receptor desensitization and internalization.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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