Thermo Fisher Scientific TNFSF10 Monoclonal Antibody (OTI12E12), TrueMAB
Human TNFSF10 단백질을 인식하는 Mouse monoclonal antibody로, Western blot에 적합. TRAIL 관련 세포사멸 연구에 활용 가능. 고순도 Affinity chromatography 정제, 안정적인 액상 형태로 제공. 연구용 시약으로 다양한 세포 생물학 연구에 유용.
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Thermo Fisher Scientific TNFSF10 Monoclonal Antibody (OTI12E12), TrueMAB
Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 39–281 of human TNFSF10 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TRAIL (TNFSF10) is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It preferentially induces apoptosis in transformed and tumor cells but does not appear to affect normal cells, despite being expressed at significant levels in most tissues.
TRAIL interacts with multiple TNF receptor family members, including TRAILR1 (DR4), TRAILR2 (DR5), TRAILR3 (DcR1), and TRAILR4 (DcR2), as well as the decoy receptor OPG. Its binding triggers activation of MAPK8/JNK, caspase 8, and caspase 3 pathways.
TRAIL is a type II membrane protein expressed in various human tissues and plays a key role in apoptosis and NF-κB activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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